Careers at Calysta

Calysta is headquartered in Menlo Park, CA. The company is a leader in the development of advanced synthetic biology to create the building blocks of high value sustainable products including nutritionals, industrial materials and consumer products. We bring together capabilities in gene synthesis, computational design, and protein and pathway engineering. Join our team and build the future with us. Contact us at hr@calysta.com.

Analytical Scientist/Associate Scientist

Calysta is hiring a highly motivated Analytical Scientist or Analytical Associate Scientist to become a key contributor to our analytical chemistry team.

Reports

Director, Analytical Science

Responsibilities:

  • Develop, validate and implement new and improved methods of chemical analysis.
  • Perform routine & non routine chemical analysis using GC, GCMS, HPLC, LCMS and other analytical equipment.
  • Oversee the technical transfer of methods between laboratories.
  • Develop, write and update SOP as required.
  • Conduct biochemical and enzymatic assay with high throughput format.
  • Data entry, processing, analysis and management.
  • Maintain laboratory equipment and consumable stock levels.
  • Communicate effectively with various cross-functional teams.

Requirements:

  • PhD or MS in Chemistry or related subject.
  • >4 years of experience working in an analytical laboratory in industry setting is preferred.
  • Experience with a variety of modern analytical techniques including GC, GCMS, HPLC, LCMS, and UV spectroscopy.
  • Experience with QTOF MS is a plus.
  • Team player with ability to work under own initiative.
  • Strong organizational, interpersonal, and written skills.
  • Experience with writing and reviewing SOPs.
  • Critical thinking and problem-solving skills along with multi-tasking.
  • Previous hands on experience with automation equipment is an advantage.

Seniority Level

Associate

Industry

  • Research
  • Biotechnology

Employment Type

Full-time

Job Functions

  • Research

Sr./Jr. Downstream Process Development Engineer

Location:
Wilton, Redcar, UK

Job Description

Calysta is an innovator in sustainable products to improve worldwide food security. Calysta is developing and commercializing FeedKind® protein, a sustainable and traceable alternative feed ingredient for fish, livestock and pet nutritional products. Produced via a natural fermentation, FeedKind® is non-GMO and price-competitive with existing sources of protein.

Calysta applies proprietary biological and chemical engineering technologies to create both valuable cost- and performance- related advantages over current biological processes.

Calysta’s core gas fermentation technology platform combines sophisticated biological engineering with a suite of unique, market-leading reactor technologies to enable commercial-scale production of Calysta’s FeedKind® protein and future protein ingredients.

We are looking for candidates with exceptional technical skills, high motivation and creativity to become a key contributor in the development of downstream processes to manufacture novel protein ingredients. Join our team and build the future with us.

As a Sr./Jr. Downstream Process Development Engineer, you will be a key member of our technical team, responsible for the process development and the commercial scale up of innovative microbial derived proteins. The engineer will be involved in both laboratory and pilot plant processing trials/testing, optimization of key process operating parameters from the lab to pilot plant scale, and technology transfer to manufacturing facilities.

Reports to:
Head of Technology

Responsibilities:

  • Lead development and improvement of downstream processes at bench, pilot and commercial scales to optimize purification, recovery and concentration of various protein fractions derived from microbial biomass.
  • Utilize a variety of relevant techniques and unit operations (centrifugation, filtration, evaporation, distillation, etc.) in developing cost-effective separation processes to recover and separate proteins from complex fermentation broth.
  • Create and execute short term (bench and kilo pilot) and long term (large pilot to commercial) technology projects through internal development and external collaboration.
  • Perform data analysis modelling and simulation of current or proposed process alternatives to develop understanding of the tradeoffs between process parameters, costs and product functionality.
  • Develop mass balances, process flow diagrams P&IDs, economic analysis, SOPs & batch records.
  • Work closely with Process Development/Food Science team to assess products, developing critical understandings of the products from both process and formulation changes.
  • Manage projects with local technical technology partners and liaise with R&D team in California.
  • Oversee equipment selection, procurement, installation and start-up – calculate capital cost and scale up commercial process.
  • Provide technical expertise in process development supporting global protein business strategy.
  • Participate in the establishment and management of best practices for data integrity and reporting compliance in a food GMP environment.
  • Mentor and supervise staff, provide technical reports and presentations and communicate results and challenges to key stakeholders.
  • Contribute to the company’s intellectual property (IP) portfolio and assist on preparation of patent applications.

Requirements:

  • Ph.D (preferred) or MS or BS in chemical engineering, chemistry, food science or related field of study.
  • 5-15+ years of relevant industry experience in protein process development and /or manufacturing of food ingredients for Sr. Downstream Process Engineer or 2–8+ years for Jr. Downstream Process Engineer.
  • Demonstrated hands on experience of pilot and/or industrial scale unit operations and equipment for food ingredient manufacturing.
  • In depth technical knowledge of downstream processing equipment including centrifugation, MF, UF/DF, multi-effect evaporation, homogenization, chromatography, extrusion, spray drying, lyophilization, pasteurization or thermal process, etc.
  • Experience with design of experiments and statistical process control.
  • Understanding of engineering/processing issues involved in scale-up and possesses both practical and analytical skills to implement relevant scale-down models.
  • Experience with process modeling and simulation using computational tools – mass balance, cost estimation, etc.
  • Understanding of basic protein biochemistry, microbiology and fermentation desired.
  • Supervision experience desired.
  • Excellent written and verbal communication.vAbility to collaborate in a cross-functional team of engineers, scientists, operators, vendors, regulatory experts, food application scientists, marketing people and partners/collaborators.
  • Familiarity with cGMPs, GLPs, GDPs and ICH guidelines a strong plus.
  • Domestic and international travel (up to 25%) required, including liaising with R&D center in California.

Sr./Jr. Process Engineer

Location:
Wilton, Redcar, UK

Job Description

Calysta is an innovator in sustainable products to improve worldwide food security. Calysta is developing and commercializing FeedKind® protein, a sustainable and traceable alternative feed ingredient for fish, livestock and pet nutritional products. Produced via a natural fermentation, FeedKind® is non-GMO and price-competitive with existing sources of protein.

Calysta applies proprietary biological and chemical engineering technologies to create both valuable cost- and performance- related advantages over current biological processes.

Calysta’s core gas fermentation technology platform combines sophisticated biological engineering with a suite of unique, market-leading reactor technologies to enable commercial-scale production of Calysta’s FeedKind® protein and future products.

The company has developed a broad international portfolio of patents to protect its proprietary technology. In addition, Calysta continues to actively file applications on new technologies and products across species and markets.

We are looking for candidates with exceptional technical skills to become a key contributor to our engineering teams. Join our team and build the future with us.

Reports to:
Senior Director of Engineering

Responsibilities:

  • Lead optimization of fermentation processes through experimental design, planning and execution.
  • Lead development and improvement of downstream processes at bench, pilot and commercial scales to reduce capital and operating cost.
  • Perform data analysis to develop understanding of the tradeoffs between process parameters and key performance indicators.
  • Develop and implement potential novel processes to improve production rate, yield and operating efficiency.
  • Oversee equipment selection, procurement, installation and start-up.
  • Experience of food, feed or other regulatory controlled industries would be an advantage.
  • Perform process modeling and simulation to optimize and predict performance at various operating conditions.
  • Supervise junior staff members.

Requirements:

  • Ph.D (preferred) or MS or BS in chemical engineering, bioengineering or related field of study.
  • 5-15+ years of relevant industry experience in process engineering for Sr. Engineer or 2–8+ years for Jr. Engineer.
  • In depth technical expertise in operating and optimizing bio/chemical-reactor/fermentation processes at bench scale, preferably pilot plant and/or manufacturing scale.
  • In depth technical knowledge of downstream processing equipment including centrifugation, UF/DF, multi-effect evaporation, homogenization, extrusion, spray drying, lyophilization, etc.
  • Experience with design of experiments and statistical process control.
  • Experience with process modeling and simulation using Aspen Plus, ANSYS Fluent or other computational tools.
  • Supervision experience desired.
  • Excellent written and verbal communication.
  • Ability to collaborate in a cross-functional team of engineers, scientists, operators, vendors and partners/collaborators.
  • Strong technical and analytical proficiency, self-motivated, creative, and flexible in a fast-moving environment.
  • Some travel for work including commissioning new plants outside of the country.

Analytical Research Associate/Assistant

Calysta is hiring a highly motivated Research Associate/Assistant to become a key contributor to our analytical chemistry team.

Reports to:
Director, Analytical Science

Responsibilities:

  • Perform routine & non routine analytical chemical testing analysis using GC, GCMS, HPLC, LCMS and other analytical equipment.
  • Conduct biochemical and enzymatic assay with high throughput format.
  • Develop, validate and implement new and improved methods of chemical analysis.
  • Data entry, process, analysis and management.
  • Maintain laboratory equipment and consumable stock levels.
  • Oversee the technical transfer of methods between laboratories.
  • Communicate effectively with various cross-functional teams.
  • Develop, write and update SOP as required.

Requirements:

  • BS or MS in Chemistry or related subject.
  • >2 years of experience working in an analytical laboratory in industry setting is preferred.
  • Experience with a variety of modern analytical techniques including GC, GCMS, HPLC,
    LCMS, and UV spectroscopy.
  • Team player with ability to work under own initiative.
  • Strong organizational, interpersonal, and written skills.
  • Writing and reviewing SOP.
  • Critical thinking and problem-solving skills along with multi-tasking.
  • Previous hands on experience with automation equipment is an advantage.

Interested candidates should send their CV and cover letter to HR@calysta.com