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Calysta Shows 8-Fold Improved Gas Fermentation in ARPA-E Program

CALYSTA

1140 O’Brien Drive
Menlo Park, CA 94025
650-492-6880
www.calysta.com

For Immediate Release

Menlo Park, CA – July 9, 2014 – Calysta, Inc. (www.calysta.com), today announced the company has achieved 8-fold improved performance over traditional fermentation technologies in a high mass transfer bioreactor. The bioreactor technology is under development for efficient methane-to-liquids fermentation processes, enabling rapid, cost-effective methane conversion into protein, industrial chemicals and fuels.

The improved performance was achieved in the research phase of a program funded in part by the Department of Energy’s ARPA-E program (http://arpa-e.energy.gov) under the REMOTE program (Reducing Emissions using Methanotrophic Organisms for Transportation Energy), awarded in September 2013. Calysta develops sustainable industrial products using novel natural gas conversion technology using methane.

“Stirred tanks, which are traditionally used for fermentation processes, are extremely inefficient for gas-fed fermentation, achieving only a small percentage of the potential productivity at high cost,” said Josh Silverman, Ph.D., Calysta Chief Technology Officer. “Calysta’s technology is the only validated, commercial scale process available to directly convert natural gas into biological products. Using Calysta’s proprietary reactor design – from our recent acquisition of BioProtein – we have now demonstrated the ability to substantially improve the rate and efficiency of methane usage in a bioreactor. The improved technology platform we are developing can be applied to a wide range of gaseous feedstocks and biological products, addressing the key bottlenecks in developing low cost, sustainable fermentation processes.”

Calysta’s Biological Gas-to-Liquids® platform is based on biological conversion of methane, a greenhouse gas ~20 times more harmful than carbon dioxide. Methane is generated by the natural decomposition of plant materials and is a component of natural gas. Methane is also generated from society’s organic wastes and is produced from such activities as waste-water treatment, decomposition within landfills and anaerobic digestion. However, other gaseous feedstocks such as carbon dioxide, carbon monoxide, and hydrogen are also abundant in specific geographies around the world.

“Gaseous feedstocks such as methane represent the next generation of biological feedstocks due to their abundance, sustainability, low cost, and the beneficial climate impact of their capture,” Dr. Silverman added. “However, due to limited solubility, optimizing and improving reactor technology is a key bottleneck in the successful deployment of gas-fed biological systems. It is important to note that Calysta’s new developments in this area can be applied to a wide range of both feedstocks and products.”

Calysta, Inc. (www.calysta.com) Menlo Park, CA, is an innovator in industrial products from sustainable sources. Calysta Energy is developing new Biological Gas-to-Liquids® and Biological Gas-to-Chemicals® technologies using methane, the primary component of natural gas. The technology allows conversion of a plentiful energy resource into high value chemicals and transportation fuels with cost and performance advantages over current processes. Calysta Nutrition develops and commercializes fish and livestock nutritional products based on gas fermentation of methane. Calysta Nutrition has operations in Stavanger, Norway.

Contact:
Calysta: Lyn Christenson, lyn@linkagesgroup.com, 650.492.6880, ext 200, or Calysta Media Information, info@calystaenergy.com.

Calysta Demonstrates Lab-Scale Production of Lactic Acid From Methane – Completes Successful First Stage of Multi Year R&D Development Collaboration With NatureWorks

CALYSTA

1140 O’Brien Drive
Menlo Park, CA 94025
650-492-6880
www.calysta.com

For Immediate Release

Menlo Park, CA – June 16, 2014 – Calysta, Inc. (www.calysta.com) today announced it has successfully fermented methane into lactic acid, under a research collaboration with NatureWorks. Lactic acid is the building block for NatureWorks Ingeo™ lactide intermediates and polymers used in consumer and industrial products worldwide.

The joint development program, started in June 2013 between Calysta and NatureWorks, is focused on creation of a commercially viable methane-to-lactic-acid process. The key aims are providing a structurally simplified, lower cost Ingeo production platform and diversifying NatureWorks’ feedstock portfolio.

“This important milestone was achieved ahead of schedule, and demonstrates the capability of Calysta’s proprietary Biological Gas-to-Chemicals® synthetic biology platform to create new manufacturing pathways using methane as an advantaged and sustainable feedstock,” said Alan Shaw, Ph.D., Calysta President and CEO. “Calysta offers NatureWorks innovative biological tools to activate a broader array of greenhouse gas feedstocks supporting NatureWorks’ commitment to feedstock diversification.”

A greenhouse gas ~20 times more harmful than carbon dioxide, methane is generated by the natural decomposition of plant materials and is a component of natural gas. Methane is also generated from society’s organic wastes and is produced from such activities as waste-water treatment, decomposition within landfills and anaerobic digestion. If successful, the technology could directly access carbon from any of these sources.

While the critical lab scale first stage of the project has confirmed methane conversion to lactic acid, much additional development work remains. A full demonstration of commercial feasibility may require up to five years of development effort. The companies will share commercialization rights for select products developed under the agreement.

Calysta, Inc. (www.calysta.com), Menlo Park, CA, is an innovator in industrial products from sustainable sources. Calysta Energy is developing new Biological Gas-to-Liquids® and Biological Gas-to-Chemicals® technologies using methane, the primary component of natural gas. The technology allows conversion of a plentiful energy resource into high value chemicals and transportation fuels with cost and performance advantages over current processes. Calysta Nutrition develops and commercializes fish and livestock nutritional products based on gas fermentation of methane. Calysta Nutrition has operations in Stavanger, Norway.

Contact:
Calysta: Lyn Christenson, lyn@linkagesgroup.com, 650.492.6880, ext 200, or Calysta Media Information, info@calystaenergy.com.

Calysta Acquires BioProtein A/S: Proven Methane to Feed Technology – Enters $370 Billion Nutritional Market with Approved Product

CALYSTA

1140 O’Brien Drive
Menlo Park, CA  94025
650-492-6880
www.calysta.com

For Immediate Release

Menlo Park, CA – May 20, 2014  – Calysta Energy, Inc. (www.calysta.com) today announced the acquisition of BioProtein A/S (www.bioprotein.no), based in Stavanger, Norway.  Through this acquisition, Calysta is entering the rapidly growing $370 billion nutritional market for fish and livestock feed and feed additives.  Calysta is a developer of novel natural gas conversion technology using methane for high value chemicals and fuels.  The BioProtein technology is the only commercial scale process available to directly convert natural gas into biological products.  BioProteinTM, the protein feed produced using BioProtein’s technology,  is approved for sale and has been commercially marketed in the European Union.

Combining its proprietary BioGPS™ technology platform with technology from BioProtein, Calysta intends to produce proteins and other key ingredients of high nutritional value through the fermentation of methane, the primary component of natural gas.  These nutrients can be used to improve the quality and sustainability of commercial fish and animal feed.  In particular, the high-quality protein generated by Calysta’s process can serve as a direct replacement for fish meal, a major component of many commercial livestock feeds.  Fish meal is currently produced from wild, commercially caught fish, adding unsustainable pressure to ocean ecosystems.

“With this acquisition, Calysta intends to expand our methane conversion portfolio into a new high growth market, significantly accelerating market introduction of products based on our combined technology,” said Alan Shaw, Ph.D., Chairman, President and CEO. “Demand is strong in the commercial fish and agriculture market for new sustainable protein sources. BioProtein’s expertise in process technology and nutrition metabolism in animal health complements Calysta’s broad capabilities in synthetic biology and biocatalysis for development of methane as a new biological feedstock.”

”We are excited to join forces with Calysta,” said Torkell Gjerstad, Managing Director at IRIS R&D Invest, BioProtein’s major shareholder. “The combined company will have the technology, team and market understanding to ensure the fullest attention to both the nutrition and chemicals business segments. BioProtein’s fermentor technology has been proven in full scale commercial operations, and its extension into the chemicals market will further strengthen the leading position of a sound, commercially attractive business case in a broad set of industry applications.”

Beyond providing a sustainable replacement for fish meal that does not compete with any human food sources, Calysta’s technology also provides a direct route to key vitamins and other health promoting compounds for animal feed.  Carbohydrates, amino acids, lipids and other vitamins can be produced from methane, as well as other key compounds to improve the health and quality of livestock while reducing the need for antibiotics or hormones.  Calysta expects to evaluate construction of a manufacturing facility in the United States.

To reflect the new multi-industry focus, Calysta Energy, Inc. is changing its name to Calysta, Inc. The new company will have two primary business units.  Calysta Energy will continue the current programs in development of its Biological Gas-to-Liquids® and Biological Gas-to-Chemicals® technologies using methane as a feedstock for the production of fuels and chemicals.  Calysta Nutrition will focus on the development of a range of nutritional products from methane.  Alan Shaw, Ph.D., currently Calysta’s Chairman, President and CEO, will continue in those roles in the new entity.  Both companies are privately held.  Further terms were not disclosed.

About Calysta

Calysta, Inc. (www.calysta.com), Menlo Park, CA, is an innovator in industrial products from sustainable sources. Calysta Energy is developing new Biological Gas-to-Liquids® and Biological Gas-to-Chemicals® technologies using methane, the primary component of natural gas.  The technology allows conversion of a plentiful energy resource into high value chemicals and transportation fuels with cost and performance advantages over current processes. Calysta Nutrition develops and commercializes fish and livestock nutritional products based on gas fermentation of methane.  Calysta Nutrition has operations in Stavanger, Norway.  It was created from Calysta’s acquisition of BioProtein AS in 2014.

Contact:
Calysta: Lyn Christenson, lyn@linkagesgroup.com, 650.492.6880, ext 200, or Calysta Media Information, info@calystaenergy.com.

LLNL Partnership with Calysta Works to Convert Natural Gas to Liquid Fuel

CALYSTA Energy™

1140 O’Brien Drive
Menlo Park, CA  94025
650-492-6880
www.calystaenergy.com

LLNL Contact: Anne M. Stark
Phone: (925) 422-9799
Email: stark8@llnl.gov

Calysta Energy Contact: Lyn Christenson
Phone: (650) 492.6880, ext. 200
Email: lyn@linkagesgroup.com

For Immediate Release

January 15, 2014

LLNL Partnership with Calysta Works to Convert Natural Gas to Liquid Fuel

In an effort to put to good use natural gas (methane) that might otherwise become pollution, Lawrence Livermore National Laboratory is collaborating with start-up company Calysta Energy on a new technology to convert natural gas to liquid fuel.

The process involves taking natural gas from oil and gas operations, and converting it to methanol that can be used as a fuel or converted to other useful chemicals. Often small amounts of natural gas produced at oil and gas operations are flared off or vented into the environment when the amount does not justify a pipeline to transport the gas.

“With this technology, we would have a small portable reactor that would convert natural gas to a liquid fuel,” said Joshuah Stolaroff, the lead Lawrence Livermore scientist on the project. “The liquid is much more valuable, and transportable, than natural gas in its gaseous form. If the technology works well, it could give the United States a new option for using our large reserves of natural gas.”

Biologically engineered enzymes, produced by Calysta, would be used as the catalyst for the conversion to liquid fuel. Enzymes have been used for years in the pharmaceutical industry, however, Stolaroff said their use in the energy sector has been limited.

“Calysta is seeing strong interest from a number of groups in this technology,” said Josh Silverman, chief scientific officer and founder of Calysta Energy. “Our main focus is the biological conversion of methane as a route to extracting the most value from one of our most abundant domestic energy resources. We see a unique opportunity in partnering with LLNL to develop game-changing technology to advance the underlying biology.”

Silverman said Calysta is interested in the partnership because of LLNL’s technical capabilities in nanostructures, reactor technology and 3D printing of substrates in which the enzymes would lie on top.

Most chemical reactions of interest for a better clean energy economy are already routinely carried out in nature. These reactions include the conversion of sunlight to chemical energy, the transfer of carbon dioxide into and out of solution, the selective oxidation of hydrocarbons (including methane to methanol), the formation of carbon-carbon bonds (including methane to ethylene), and the formation and dissolution of silicon-oxygen bonds (including enhanced mineral weathering).

Conventional industrial approaches to mimic those natural processes require catalysts that will work in industrial conditions. Certain enzymes have been identified that carry out each of these reactions with high selectivity under mild conditions – a specialty of Calysta Energy.

“This presents an opportunity for industrial biocatalysis and biomimetics to fill the gap between current technology and natural capabilities,” Stolaroff said. “We identified methane-to-methanol technologies as having an exciting market and environmental opportunity. Catalytic methane conversion at ambient conditions would have an application to the growing shale gas industry and associated methane emissions.”

Stolaroff said natural gas mitigation strategies are also needed for a variety of sources, including oil and gas operations, coal mines, agriculture and organic waste, with a range of concentrations and characteristics. The only catalysts available to convert natural gas to other hydrocarbons at ambient temperature and pressure or from low-concentration streams are enzymes in certain type of bacteria.

“Harnessing these enzymes could greatly expand the range of methane sources that would be economic to mitigate and could have additional industrial applications,” he said.

The project is funded by the LLNL Laboratory Directed Research and Development (LDRD) program.

About Calysta Energy™
Calysta Energy, Inc. (www.calystaenergy.com), Menlo Park, Calif., is developing new Biological Gas-to-Liquids® and Biological Gas-to-Chemicals® technologies using methane, the primary component of natural gas. The technology allows conversion of a plentiful energy resource into high value chemicals and transportation fuels with cost and performance advantages over current processes. BioGTL®, Biological Gas-to-Liquids®, BioGTC®, and Biological Gas-to-Chemicals® are trademarks of Calysta Energy.

About Lawrence Livermore National Laboratory
Founded in 1952, Lawrence Livermore National Laboratory (www.llnl.gov) provides solutions to our nation’s most important national security challenges through innovative science, engineering and technology. Lawrence Livermore National Laboratory is managed by Lawrence Livermore National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration.

Lawrence Livermore National Laboratory news releases and photos are also available at https://www.llnl.gov/news/newsreleases/.